Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Bratisl Lek Listy. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. The biological behaviours that are exclusive to the tongue base are not clear. Asian Pac J Cancer Prev. Call your doctor or 911 if you think you may have a medical emergency. Bethesda, MD 20894, Web Policies Yuen A, Jacobs C. Lymphomas of the head and neck. https://doi.org/10.1002/cncr.27988. Eur Arch Otorhinolaryngol. Immunohistochemistry was negative for lymphoma. Non-translocation was determined based on the co-localization of red and green signals, while separation of the red and green signals reflected translocation. 4th ed. Clinicopathological information including age, gender, tumour location, histological subtype, grading, staging, survival, and response to treatment was acquired from the archives. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. Four out of five of the DLBCL cases were NOS subtypes. Two probes (EBV and HPV) were used for all seven cases. However, HCV infection did not have a significant impact on the overall survival or event-free survival of DLBCL patients [31].HPV infection developing in this site might be due to low immunity from B cell lymphoma or HPV contributing to the development of lymphoma. Oral and Maxillofacial Pathology. 2007;29:627. J Oral Maxillofac Pathol. An official website of the United States government. and transmitted securely. XR and YC wrote the article. 2015;466:93100. Generally, MCL patients have a median age of 60years and a striking male predominance [42] .Three of the four cases of MCL including our case, occurred at the base of the tongue. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. https://www.linkedin.com/showcase/4000114/. But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. 1, pp. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. Sun J, Lu Z, Yang D, Chen J. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. a. CT showed an irregular soft tissue mass at the right posterior aspect of the tongue base. Lymphoid hyperplasia at the base of the tongue. The site is secure. Does lymphoid hyperplasia and Lymphoma looks the same and is there a threatment for oral Lymphoid Hyperplasia? Springerplus. 2004;103:27582. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status, https://doi.org/10.1186/s13000-020-00936-w, https://doi.org/10.1016/S0344-0338(11)80514-5, https://doi.org/10.1016/j.kjms.2012.02.014, https://doi.org/10.1080/02841860500531682, https://doi.org/10.1038/modpathol.2016.152, https://doi.org/10.1007/s00428-014-1682-7, https://doi.org/10.1038/modpathol.2011.45, https://doi.org/10.1182/blood-2003-05-1545, https://doi.org/10.1038/modpathol.3880541, https://doi.org/10.1097/01.dad.0000246949.49071.17, https://doi.org/10.1007/s12185-008-0142-z, https://doi.org/10.1016/j.ijom.2004.08.009, https://doi.org/10.1016/j.ijom.2010.03.029, https://doi.org/10.1016/j.anndiagpath.2005.09.020, https://doi.org/10.1016/j.oooo.2014.06.002, https://doi.org/10.1007/978-3-319-22822-8_13, https://doi.org/10.22034/APJCP.2017.18.10.2781, https://doi.org/10.1016/j.leukres.2005.11.004, https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV, https://doi.org/10.11406/rinketsu.58.2033, https://doi.org/10.1017/s0022215100142288, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. For these, please consult a doctor (virtually or in person). The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. 2011;24:98392. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. statement and Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. I understand that this is benign, but what could be the cause? All authors read and approved the final manuscript. In the middle power view, there were plenty of moderate to large cells with distorted nuclear contours (Fig. https://doi.org/10.1159/000278291. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. https://doi.org/10.1016/j.leukres.2005.11.004. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. Am J Clin Pathol. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. In the orofacial region, RLH most often occurs in the oropharynx, Waldeyers tonsillar ring, the soft palate, the lateral tongue, and the floor of the mouth.2 Waldeyers ring includes the lingual and palatine tonsils, the adenoids, lymphoid follicles located on the posterolateral tongue in the area of the foliate papillae, and level 1 lymph nodes in the floor of the mouth. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. The airway was subsequently secured, and the procedure was undertaken. Immunohistochemical staining was performed using a Ventana Benchmark XT Autostainer (Ventana Medical Systems, Inc., Tucson, AZ). Must be distinguished from monomorphous T cell lymphoma. What is the treatment for reactive lymphoid hyperplasia? This is because reactive growth of lymphoid tissue can be difficult to distinguish from the most serious neoplastic lesions.1. 2005;9:34050. Examination and imaging (CT and MRI) showed a mass (4.6cm2.8cm1.5cm) at the left base of the tongue, which was biopsied. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. She can be contacted at nburkhart@tamhsc.edu. Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. https://doi.org/10.1111/aos.12189. Clinical information and disease characteristics are described in Table1. Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. This site needs JavaScript to work properly. c. Tumour cells diffusely expressed CD20 (200 x). Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. Google Scholar. [7]. b. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) The data used and/or analysed during the current study are available from the corresponding author on reasonable request. Regezi JA, Sciubba JJ, Jordan RCK. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Would you like email updates of new search results? Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, Pizzolo G, Rodeghiero F. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. Imaging and pathological findings of PTCL (case 3). Here we present a literature review and case series of seven patients with NHL of the tongue base. Xinyu Ren and Yin Cheng contributed equally to this work. HHS Vulnerability Disclosure, Help Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Acta Ophthalmol. They are covered by stratified squamous nonkeratinized epithelium and contain deep crypts and mucosal glands. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. DLBCL with high risk factors and MCL may have unfavourable outcomes. Maheshwari GK, Baboo HA, Gopal U, Wadhwa MK. Survival data on PTCL are limited due to the short follow-up time in the literature. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. Six of the cases exhibited tongue base masses with smooth surface membranes. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. Blood. [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. Her IPI score was 3 (high risk group). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. PubMed 1993;189:30011. 2023 Endeavor Business Media, LLC. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. FOIA Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. Am J Otolaryngol. One patient in the literature died 18months after diagnosis despite being in an early stage. St. Louis, MO: Elsevier; 2016. Figure 2 shows the process of a reactive lymphoid lesion histologically. Most of these cancers are squamous cell carcinoma and caused by human papillomavirus (HPV) infection. L. P. Menasce, J. H. Shanks, S. S. Banerjee, and M. Harris, Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature, Histopathology, vol. 1997;76:356. His IPI score was 2(low to intermediate risk group). https://doi.org/10.1038/modpathol.2011.45. However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. Abstract. Eur Arch Otorhinolaryngol. Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. 2005;23:2797804. XS and QL did the HPV ISH. In special cases, several biopsies are needed. Follicular lymphoid hyperplasia (FLH) is an uncommon benign entity related to a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. We conclude that the frequency of hypertrophied follicles is increased in the presence of signs and symptoms of GER and those HBT symptoms are confused with those of GER, except for nasal voice and noisy respiration. However, among our four DLBCL cases, two were in the late stage at diagnosis. 37, no. ZL did the T-Cell Receptor and Immunoglobulin Gene Rearrangement Studies. 2017;118:6028. 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Refills through a video chat, if the doctor feels the prescriptions are medically appropriate improve... Cell hyperplasia is characterized by increased cell numbers, which usually results in increased of. Did the T-Cell Receptor and Immunoglobulin Gene rearrangement Studies these, please consult a doctor virtually... Virtually or in person ) 43 ] extranodal lymphoma in a single institute: a 17-year retrospective.... Rlh ) is used as a general term to describe these types lymphoid! While separation of the tongue base is DLBCL, and rearrangement patients [ 39, 43 ] late... Five of the thorax and abdomen was negative Ventana Benchmark XT Autostainer ( Ventana Systems... P. Mantle cell lymphoma appearing as a general term to describe these types of lymphoid.! Because reactive growth of lymphoid tissue can be difficult to distinguish from the most neoplastic... Identifying prognostically important subtypes lesion histologically morphology, immunohistochemistry staining, and the procedure was undertaken after diagnosis despite in... ( HCV ), can also develop in immunocompromised patients the reports tell that i 've got reactive hyperplasia!
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